Laboratory diagnosis of antiphospholipid syndrome
نویسندگان
چکیده
منابع مشابه
Laboratory Diagnosis of Antiphospholipid Antibodies
Antiphospholipid antibodies may be associated with venous thromboembolism and/or arterial thromboses or miscarriages; their heterogeneity complicates the laboratory diagnosis. For a long time, they were believed to be directed against anionic phospholipids. More recently, it has been demonstrated that these antibodies are directed at plasma proteins bound most of the time to a phos-pholipid sur...
متن کاملLaboratory Diagnostics of Antiphospholipid Syndrome.
Diagnosis of antiphospholipid syndrome (APS) lies in the recognition of antiphospholipid antibodies (aPL). As standardization of tests for the detection of aPL is far from being optimal and reference material is not available, inappropriate diagnoses of APS are not unusual. In the last few years, the concept of triple test positivity has emerged as a useful tool to identify patients with APS. C...
متن کاملReview: Laboratory Evaluation of the Antiphospholipid Syndrome
Th e antiphospholipid syndrome (APS) was fi rst described in 1986. Th e original association of this hypercoagulable state with anticardiolipin antibodies (aCL) resulted from the synthesis of evidence stemming from laboratory fi ndings in systemic lupus erythematosus (SLE), ie, the frequent occurrence of false-positive VDRL tests and the paradoxical observation of the so-called “lupus anticoagu...
متن کاملDiagnosis and management of the antiphospholipid syndrome.
Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy complications in the presence of persistent antiphospholipid antibodies (APLA). Laboratory diagnosis of APLA depends upon the detection of a lupus anticoagulant, which prolongs phospholipid-dependent anticoagulation tests, and/or anticardiolipin (aCL) and anti-β2-glycoprotein-1 (β2GPI) antibodies. APLA are primarily...
متن کامل[Antiphospholipid antibodies and antiphospholipid syndrome: diagnosis and management].
Antiphospholipid syndrome is an acquired autoimmune thrombophilia that produces significant morbidity and mortality. Its diagnosis requires the presence of antiphospholipid antibodies and clinical manifestations that include thrombotic phenomena and/or recurrent miscarriages. Antiphospholipid antibodies may be detected in many instances, including healthy subjects. Clinical manifestations are v...
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ژورنال
عنوان ژورنال: Reumatismo
سال: 2011
ISSN: 2240-2683,0048-7449
DOI: 10.4081/reumatismo.2007.187